What is Down Syndrome ?
Down syndrome is a condition in which a person has an extra chromosome. Chromosomes are small “packages” of genes in the body. They determine how a baby’s body forms during pregnancy and how the baby’s body functions as it grows in the womb and after birth. Typically, a baby is born with 46 chromosomes. Babies with Down syndrome have an extra copy of one of these chromosomes, chromosome 21. A medical term for having an extra copy of a chromosome is ‘trisomy.’ Down syndrome is also referred to as Trisomy 21. This extra copy changes how the baby’s body and brain develop, which can cause both mental and physical challenges for the baby.
Expert News and Articles
Science Daily: Down Syndrome
Fragile X syndrome is the most frequent cause of intellectual disability in males, affecting 1 out of 3600 boys born. For the first time, researchers have restored activity to the fragile X syndrome gene in affected neurons using a modified CRISPR/Cas9 system that removes the methylation -- the molecular tags that keep the mutant gene shut off -- suggesting that this method may be useful for targeting diseases caused by abnormal methylation.
Down's syndrome -- also known as trisomy 21 -- is a genetic disorder caused by an additional third chromosome 21. Although this genetic abnormality is found in one out of 700 births, only 20% of fetuses with trisomy 21 reach full term. But how do they manage to survive the first trimester of pregnancy despite this serious handicap? Researchers have found that children born with Down syndrome have an excellent genome in many ways -- better, in fact, than the average genome of people without the genetic abnormality.
Down's syndrome, also known as trisomy 21, is one of the most common genetic diseases. Researchers have recently analyzed the proteins of individuals with trisomy 21 for the first time: the goal was to improve our understanding of how a supernumerary copy of chromosome 21 could affect human development. The research shows that trisomy 21, far from only affecting the proteins encoded by the chromosome 21 genes, also impacts on the proteins encoded by the genes located on the other chromosomes.
Down Syndrome OPTIONs
September 2017Conference Speakers, Presentations & DeadlinesDoctors, therapists, parents, educators, advocates, scientists, researchers and loved ones gathered during the 2016 Innovations Conference.Deadlines!September 28.... Early Bird Registration EndsOctober 4..... Meet & Greet Registration EndsOctober 6.... Hotel Registration Discount EndsConference RegistrationHotel RegistrationSpeakers and TopicsMitochondrial Dysfunction and Inflammation/ Neuroinflammation in T21 and What to do About ItNorman Schwartz, MD ....My LifeLydia Winans, student and self-advocate....Risk Reduction for Leukemia in those with Down SyndromeLaurette Janak....Brilliant Learning Tips for Students with T21JoQueta Handy, PhD, SLP-CCC....Hope Unexpectedly Awaits in Sound: Tomatis Listening TherapyEllen Young, PhD, MA, RCTC....Application of Near-infrared LEDs to Improve Cognition ...and Improve Language... Can Photobiomodulation Strengthen Connections in the Default Mode Network?Margaret A. Naeser, Ph.D....Cognitive Improvements with Alzheimer's Disease/Dementia Using Low Level Light TherapyAnita Saltmarche, PhD....Reflex Integration Using Low Level Light TherapyBonnie Brandes, M.Ed....Neuro-developmental Therapy and SOI (Structure of Intellect) Intelligence Can Be LearnedLinda Kane, M.CND....Growth Hormone Deficiency in the T21 PopulationRichard Levy, MD....The Science Behind Reducing Oxalate in those with Down SyndromeSusan Costen Owens, BS, MAIS....Functional Nutrition Strategies for Enhancing Digestion and Preventing Neurodegenerative DeclineGail Clayton, R.Ph, MS, CNS....The Importance of the C Cleanse and Use of Functional Predictive Biomarkers in T21Russell Jaffe, MD, PhD....Sleep, Circadian and Stem Cell Renewal Factors in the Learning Disability seen in those with Down SyndromeCraig Heller, PhD....Sponsored by: Down Syndrome Innovations Conference
Join us for the latest research and interventions to support and enrich the lives of individuals with Down syndrome.Visit our conference website for full details.Early Bird Pricing:Full conference (2 days)- $170/person Saturday, October 28th - $85/personSunday, October 29th - $85/personRegistration includes full breakfast, mid morning beverage service, plated lunch, mid afternoon beverage service, access to online conference program and free access to 2017 conference videos.Register to Attend Meet & Greet Reception$15/personOctober 28th, 6:00-8:00 pmHors d'oeuvres and drinks Please feel free to register friends and loved ones to mix and mingle at the Meet & Greet.100% of registration fees will be applied directly to conference costs.Hotel Registration
Register here.September 16-17, 2016Little Rock, Arkansas Registration for the 2016 Down Syndrome Innovations Conference already includes free access to the 2016 videos, so this is a great bonus!Note: Several speakers will include information about Green Tea Extract in the Down syndrome population in their presentations at the conference. These presentations are part of the free 2015 video access:EGCG in the Down Syndrome PopulationJohn Starbuck, PhD Thinking About Trisomy 21 – Towards a Best Practices ApproachNorman Schwartz, MDHypothyroidism and Down SyndromeErica Peirson, NDNeuroMovement: Turning the Child with Down Syndrome into a Potent LearnerAnat Baniel, ABM creatorMaternal Choline/Neurogenesis/Therapeutic Intervention for Basic Brain Cognition SupportBarbara Strupp, PhDOxidative Stress and Epigenetic Alterations in Down Syndrome: Targeted Nutritional Intervention Trail at Arkansas Children’s HospitalS. Jill James, PhDDietary Targeting of RCAN1 and Chromosome 21 Genes to Treat the Down Syndrome PopulationDana Crawford, PhDMolecular Mechanisms Engaged in Brain Prior to and Following Development of Alzheimer’s Disease Neuropathology and Dementia in Down SyndromeD. Allan Butterfield, PhDMitochrondial Dysfunction and Oxidative Stress in the Down Syndrome PopulationJorge A. Busciglio, PhDTreatment Strategies for Mitochondrial DysfunctionRichard Frye, MD PhDHealthy Digestion-Healthy Microbiome: What to Test, What Tests Mean and What to DoRussell Jaffe, MD Phd FACNOral Placement Therapy Techniques for Better SpeechMonica Purdy, MA CCC-SLPOptimized Nutrition is Essential for those with Trisomy 21. Where’s the Debate?Kent MacLeod, BSc PharmacologyThe Baby-Led Weaning Approach: An Excellent Option to Assist Babies with Down Syndrome in Transitioning to Solid FoodsJill Rabin, MS CCC-SLPGluten FreePaula Dempsey, Small Business Owner and Grandmother to child w/CeliacBalancing Minerals in the Down Syndrome PopulationMorley Robbins, MBA CHCDevelopmental and Behavioral ConsultantsAlison Wimmer, BS NeurodevelopmentalistEarly Dental Intervention to Improve Airway Size and to Correct Oral Rest PostureJames Bieneman, DDSSmall Intestinal Bacterial OvergrowthErica Peirson, NDMy Teen Life: Living with Trisomy 21Lydia Winans, student